My dog has high ALP, no symptoms. When will she be in danger?

Question

My dog has increasing ALK phosphatase levels which are now up to over 1400. All tests are normal (blood work, ultrasound, biopsy, copper staining, etc). Medicine did not help. She is currently asymptomatic. At what point or enzyme level will she be in danger or begin to have symptoms. Pet's info: Dog | Labrador Retriever | Female | spayed | 6 years and 11 months old | 180 lbs

Rodrigo Roca, DVM · Accepted Answer

Hello, thank you for your question about Daisy. There are numerous causes for elevated ALP in dogs, many of which you have ruled out by the testing described. Some dogs can experience a condition called vacuolar hepatopathy, a benign condition that we can sometimes not identify the reason for. Many of these dogs demonstrated no symptoms even with a significantly elevated ALP. There is no specific ALP level that will lead to symptoms in dogs, it is very patient dependent (some dogs are much more sensitive to mild changes). I would recommend having her liver values monitored every 4-6 months, or sooner if she develops any signs such as vomiting or inappetance. Additionally, I would consider adding Denamarin/Denosyl to her treatment regimen. Although this may not normalize her ALP it can help prevent further elevation of the value in the future. Hope this helps, good luck!

My dog has high ALP, no symptoms. When will she be in danger?

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