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My dog has side effects from Simparica & Vectra 3D. Are they safe?

Updated On September 23rd, 2025

Pet's info: Dog | Miniature Poodle | Male | neutered | 1 year and 1 month old | 15 lbs

We switched from Simparica to Vectra 3D. Simparica seemed to give him tummy upset (not uncommon for him) and lethargy. Vectra 3D I haven’t noticed that, but he seems like he’s trying to itch his back (no redness) and after two days he has a strong woody smell along his back where applied. I’m reading that the Vectra3D has very strong meds & the more you google the more scared you get reading that flea & tick meds can have fatal side effects. Can I get an opinion on both?

1 Answer

Most Helpful Answer

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Answered By Sara Farmer, DVM

Veterinarian

Published on February 4th, 2019

I think both are good products with few side effects. The topical medications do sometimes cause some irritation to the skin, even if it doesn’t seem red, but it typically does not last long. Oral preventatives in he same class as Simparica can cause gastrointestinal signs and lethargy. You could try a different oral medication like Nexgard or Bravecto - some do better with one over the other. I wouldn’t worry about the smell from the Vectra.

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