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Is my cat's Prednisone dose too high or safe for long-term use?

Updated On September 23rd, 2025

CBC showed low red blood cell count & VERY low white blood count. Vet prescribed 5mg Prednisone every 12 hrs 2nd CBC, 1 wk later showed normal red & high white blood counts. Continued Prednisone at 3/4 tablet every 12 hrs for 3 weeks. This sounds excessive to me, what do you think. Can damage occur with continued use of Prednisone? No diarrhea, No vomitting, No fever, Any suggestions would be appreciated. Thanks, Jan

1 Answer

Most Helpful Answer

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Answered By Dr. B. DVM, DACVIM (Oncology)

Veterinarian

Published on January 31st, 2019

You have a very valid question. Here is the problem, your kitty does not have a diagnosis for why the cell counts were low. This makes it difficult to know how to taper meds like pred nor how long to provide treatment. Has your kitty been tested for feline leukemia/FIV? Was there any additonal testing done other than a CBC? It really would be important for you to discuss your concerns with your family vet who should be open to a discussion about a med that can have long term side effects. We typically do slowly taper drugs like pred for several reasons and your vet will be able to tell you why he or she picked that particular tapering schedule. I hope this helps and thank you for using Petco Pet Education Center, formerly Petcoach!

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