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Can DHPP vaccine cause autoimmune issues or reactions in dogs?

Updated On September 23rd, 2025

Pet's info: Dog | Boxer | 7 years and 9 months old

Hi, Cruz has his annual tomorrow. He always gets wellness testing and the HW/Lyme test with his exam. In the past I've done titre testing. But, was considering getting him the DHPP vaccine 1 more time (I am concerned about over vaccinating). He will be 8 in a few months and has been vaccinated for DHPP at least 4 times in his life. But, since I haven't gotten him the DHPP in a few years I'm worried about a reaction or triggering an autoimmune issue. Can you please tell me what the risks are?

1 Answer

Most Helpful Answer

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Answered By Dr. Elizabeth

Veterinarian

Published on January 22nd, 2019

Vaccines are generally well tolerated by dogs and vaccine reaction rates are very low. If he has had the vaccine before without any issue, then it is unlikely that he will have a problem this time around (but it is not impossible). Definitely titer testing will tell you if the vaccine is needed and is a good idea if vaccine reactions have occurred in the past or if it makes you uncomfortable. In the US, most adult dogs will get the DHPP vaccine every 3 years once they finish the puppy series. Lasltly, some dogs will get an injection of diphenhydramine 15 minutes prior to a vaccine to decrease the potential for a reaction. Vaccine reactions include vomiting, diarrhea, facial swelling, hives, collapse (anaphylactic reaction) and can triggger autoimmune conditions. The vast majority of vaccine reactions are the less serious form. If you pet has a history of any autoimmune condition, you should discuss if vaccinations are appropriate for him. I hope this answers your questions. Please feel free to post any additional questions.

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