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Is Mirtazapine safe for cats with kidney disease and megacolon?

Updated On September 23rd, 2025

Pet's info: Cat | Domestic Shorthair | Female | spayed | 16 years and 5 months old | 11 lbs

What are the side effects and adverse reactions of the medicine Mirtazapine in felines with stable kidney disease and a mega colon?

1 Answer

Most Helpful Answer

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Answered By Sara Farmer, DVM

Veterinarian

Published on March 21st, 2018

Mirtazipine can cause serotonin syndrome which is characterized by hyperactivity, muscle tremors, vocalization and behavior changes. This is more likely at high doses but has been reported to occur at typical doses as well. It is cleared through the kidneys so a dose reduction is typically recommended for cats with decreased kidney function. Megacolon should not be a concern.

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