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My cat has a hot spot. Can I safely use Benadryl cream on it?

Updated On September 23rd, 2025

Is it safe to use benadryl cream on a cats hot spot?

1 Answer

Most Helpful Answer

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Answered By Stacey Anstaett, DVM

Veterinarian

Published on December 6th, 2018

This is not likely to cause a problem, but not ideal either. Topical Benadryl is not very effective in dogs and cats, and of course cats notoriously lick off whatever you put on them. Consider using [Zymox spray](https://www.petco.com/shop/en/petcostore/product/zymox-spray-with-5-hydrocortisone). You can pick it up from the local Petco. Place an e-collar (cone) on him/her for a couple of days. If the spot isn't improving after 3-4 days, have your cat evaluated by a veterinarian. Thanks for asking PetCoach!

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