Updated On September 23rd, 2025
Is it safe to use benadryl cream on a cats hot spot?
2 Answers
Published on December 6th, 2018
This is not likely to cause a problem, but not ideal either. Topical Benadryl is not very effective in dogs and cats, and of course cats notoriously lick off whatever you put on them. Consider using [Zymox spray](https://www.petco.com/shop/en/petcostore/product/zymox-spray-with-5-hydrocortisone). You can pick it up from the local Petco. Place an e-collar (cone) on him/her for a couple of days. If the spot isn't improving after 3-4 days, have your cat evaluated by a veterinarian. Thanks for asking PetCoach!
19Pet Parents found this answer helpful
Published on February 3rd, 2017
No, I would not put benadryl cream on it. Although quite safe on superficial wounds, cats groom and ingest most of the topical ointment you apply and therefore should be used only under direct veterinary supervision and if there are no other appropriate options. Many human ointments contain multiple other ingredients which are not necessarily safe to be swallowed. Given that it's only a small dry spot, I wouldn't be worried about it. Keep an eye on it, and if it doesn't heal, you can take Duke into the vet to have it examined.
1Pet Parents found this answer helpful
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