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My dog's Acepromazine isn't working for anxiety. Can I increase dose?

Updated On September 23rd, 2025

Pet's info: Dog | German Shepherd | Female | spayed | 6 years and 5 months old | 93 lbs

Bella weights 90 pounds and she has always given by her veterinarian ACEPROMAZINE to help her deal with her fear and anxiety. She always takes 1 tablet/25 mg 60 minutes before she is seen. One tablet seems to do nothing to her, can i give her 1 1/2 tablets of 25 mg.?

2 Answers

Most Helpful Answer

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Answered By Andrea M. Brodie, DVM

Veterinarian

Published on October 25th, 2018

Unfortunately Acepromazine does not take away fear and anxiety. It just sedates the dog, he will appear quieter, but inside, she is just as anxious, just cannot express it. There is a much better medication for that and it is called Sileo. Your veterinarian can provide you with that and give you the proper dosage for Bella. We are not in a position legally to give out dosages. In order to do legally so we would have to have a patient-veterinarian-owner relationship with you. Your veterinarian also knows your dog and the potential risks for your dog receiving acepromazine.

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    Answered By Sara Farmer, DVM

    Veterinarian

    Published on October 25th, 2018

    Acepromazine is a sedative that is used in dogs, but I typically don’t recommend it for situations where a dog might be fearful. I also don’t know the tablet size so it’s hard to say if 1.5 tablets would be safe for a dog Bella’s size. I would recommend contacting your vet before giving any medication - they might recommend a different sedative if she is anxious or fearful during vet visits, or they may want to go ahead and examine her first to make sure medication is safe for her.

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