My dog's Apoquel isn't lasting. Is twice daily dosing too much?

Question

My dog is currently on Apoquel 5.4 mg once per day. He is 25 lbs. Lately, that hasn't been lasting a full 24 hrs so his vet said that I could give him one 5.4 in the a.m. and then another 5.4 in the p.m. for two weeks and then back down to one pill again. The other choice was to give one 5.4 and a half of a 3.6 at once in the morning, which the vet advised not do that option since 5.4 and 1/2 of the 3.6 is a lot of Apoquel at once. But, isn't 5.4 twice per day a lot, too? I'm confused. Pet's info: Dog | English Cocker Spaniel | Male | neutered | 12 years and 7 months old | 25 lbs

Sara Farmer, DVM · Accepted Answer

Apoquel is dosed twice daily initially, and due to it’s pharmacokinetics I would agree that twice daily would be preferable to increasing the dose once daily. There might be some other options as well - you could ask your vet about trying Cytopoint or other medications for allergies.

My dog's Apoquel isn't lasting. Is twice daily dosing too much?

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