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Frontline for kittens: How long until fleas are gone and my home is safe?

Updated On September 23rd, 2025

After applying Frontline to a kitten, how long will it take to work? Attempting to rescue a stray that was dumped and now living under a abandoned home. Need to keep it in my bathroom a few days and wait till spay n neuter clinic opens again next week and i have 3 indoor cats. Dont want to risk my apartment or my cats to fleas. Should i keep kitty out of home till it takes effect? Thankyou.

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Answered By Angel Alvarado, LVT

Licensed Veterinary Technician

Published on October 3rd, 2018

Frontline will kill fleas within 24 hours and ticks within 48 hours. To be safe, you should also treat all your cats as well. A majority of a flea population lives off the pet, only hopping on to feed. A flea treatment and prevention program will include treatment of the pet and the environment. Use a preventative for at least 3 consecutive months, preferably year round.

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