Petco Text Logo
Petco Pet Logo

Is ProHeart 6 or Heartgard safer for my dog's heartworm prevention?

Updated On September 23rd, 2025

Pet's info: Dog | Shih Tzu | Male | unneutered | 2 years and 6 months old | 13 lbs

Is the ProHeart 6 shot safe? Is there any risk? I read on the internet death and seizure may occur I’m scared I don’t know which one to give my fur babies the shot or the heartguard chew? I also have a 7 month Shih Tzu who I want to put on the heartguard as well as my 2 year old max! Help please

1 Answer

Most Helpful Answer

Image profile

Answered By Dr. Heidi DVM, CVA, CCRT, CVTP, CVSMT, CVCH

Veterinarian, Certified Veterinary Acupuncturist, Certified Canine Rehabilitation Practitioner

Published on March 16th, 2018

There are some risks associated with any medication, but certainly those risks can be more significant with some of the injectible medications. Unfortunately, we have rarely seen some serious side effects with Proheart. I am attaching the safety information from Proheart website below. http://www.proheart6.com/ "IMPORTANT SAFETY INFORMATION: PROHEART 6 should be used in healthy dogs. Do not administer to sick, debilitated, underweight dogs or dogs that have a history of weight loss. Prior to administration, PROHEART 6 certified veterinarians should continue to assess patient health through a medical history, physical examination and if deemed appropriate, diagnostic testing. Continue to use caution when administering PROHEART 6 concurrently with vaccinations. Adverse events, including anaphylaxis, have been reported following the concomitant use of PROHEART 6 and vaccines. In some cases, anaphylactic reactions have resulted in death. Use with caution in dogs with pre-existing or uncontrolled allergic disease (food allergy, atopy or flea allergy dermatitis). Dogs receiving PROHEART 6 should be tested for existing heartworms as per the product label. In people, avoid PROHEART 6 contact with eyes. If contact with the eyes occurs, rinse thoroughly with water for 15 minutes and seek medical attention immediately. PROHEART 6 is available only to veterinarians through a restricted distribution program. Only certified veterinarians and staff can administer it. See full Prescribing Information." And here is the safety information from Heartgard's website. https://www.heartgard.com "IMPORTANT SAFETY INFORMATION: HEARTGARD Plus is well tolerated. All dogs should be tested for heartworm infection before starting a preventive program. Following the use of HEARTGARD Plus, digestive and neurological side effects have rarely been reported. For more information, contact your veterinarian or click here for full prescribing information." If you cannot remember to give Heartgard every month, then Proheart may be a better option if the risk of heartworm disease in your area is significant. I have used Heartgard in my dogs for their entire lives and have been very pleased with the product. Good luck! I hope that was helpful and answered your question. Thanks for using PetCoach.

Vote icon

1Pet Parents found this answer helpful

image
Have A Vet Question?

Book an appointment with the pros – our expert vets are here to help.

Sponsored