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How safe is Buspirone for my dog's anxiety and her liver/kidneys?

Updated On September 23rd, 2025

Pet's info: Dog | Mixed Breed Medium (23 - 60lb) | Female | unspayed | 4 years and 10 months old | 50 lbs

As my dog suffers very badly from noise anxiety, i have decided to put her on Buspirone over the firework period. I have done my research, and while they are relatively safe and a very popular choice, they are not good for dogs that have liver or kidney disease. Although my dog has never had any problems with her liver or kidney, i want to be sure that i am not doing any thing wrong by starting her on these. I have spoken to my vet and they said they will just start her on a low dose, but i was

1 Answer

Most Helpful Answer

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Answered By Linda G, MS, DVM

Veterinarian

Published on August 22nd, 2018

Hello. This is a common anti-anxiety medication for both dogs & cats & it does seem to be quite safe when used within the parameters of its suggested use. As with any long-term medication, regular veterinary visits with blood work to follow liver & kidney values are necessary & required. If at any time, there are elevations of the liver/kidney enzymes or concerns, then one will need to re-evaluate the need for the medication or the risk vs benefits of continuing the medication. Many pets can safely be maintained on these medications for years & live happier, much more comfortable lives. Thanks for using Petco Pet Education Center, formerly Petcoach.

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