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My dog's epilepsy meds stopped working. What can I do?

Updated On September 23rd, 2025

Pet's info: Dog | Chihuahua | Male | neutered | 7 years and 11 months old

Hi so ceaser was back at the vets today His epilepsy pills are not working his fits have returned with a vengence. He now has a urinary tract and bowel infection and is on antibiotics. The vet is baffled as to why his pills have stopped working. Although ceaser is still eating and drinking he is just really depressed and sleeps alot. The vet thinks if his quality of life has changed maybe we should think about euthanasia. Im so sad and confused i dont know what to do am i being selfish

3 Answers

Most Helpful Answer

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Answered By Ricardo Fernandez, DVM

Veterinarian, Veterinary Oncology Resident

Published on August 3rd, 2018

Thanks for using Petco Pet Education Center, formerly Petcoach! I do not think that you are being selfish at all. You care about him which is good. It is common for dogs with epilepsy to eventually need more medications added to their anti-seizure medication protocols. There are several anti-seizure medications that can be considered including phenobarbital, potassium bromide, Keppra, zonisamide, among many others. I would encourage you to discuss with your veterinarian about other anti-seizure medications. Often times dogs with epilepsy respond favorably to other medications. Good luck and have a great day!

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    Answered By Eryn Taormina, DVM

    Veterinarian

    Published on December 2nd, 2018

    Hi there! I'm sorry to hear about Deedee's troubles. However I would not adjust the dose of seizure medications unless it's done so under the direct supervision of Deedee's veterinarian. I would give them a jingle and let them know the seizures are worsening as you're weaning off of the Keppra. They can make the adjustment based on her history. One thing you can try that is usually very benign and has minimal negative side effects as far as we know is CBD oil. Check out 7 leaf pet. I never use CBD oil by itself, or in place of seizure medications, but have found in some cases that when used as adjunctive therapy, it can help a lot. Just be sure to call Deedee's vet right away though, and let them know what's going on! Best of luck!

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    Answered By Dr. Leigh, DVM

    Veterinarian

    Published on October 13th, 2017

    Keppra is used to treat seizures so you could talk to your vet about trying it or a different anti-seizure medication. You could also have your dog evaluated by a neurologist if your vet is not able to get his seizures under control. A neurologist may be able to find the best medication and/or combination of medications to help your dog.

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