My dog's limping on Lyme meds, but tests are negative. Second opinion?

Question

My dog was diagnosed with Lyme disease and has been on doxycycline, after having a fever and lameness and swelling on all lower legs, the first week of antibiotics he seemed to get better, now he has days where he is okay and days he’s limping. The swelling has seemingly stayed gone with the antibiotics. The vet we brought him to is adamant that this is Lyme even though his test came back negative. Could this be something else? Should I get a second opinion? Pet's info: Dog | American Staffordshire Terrier | Male | unneutered | 40 lbs

Laura Johnson VMD · Accepted Answer

Hi, thanks for using Petco Pet Education Center, formerly Petcoach! Poor Max! Most dogs with Lyme improve on doxycycline with in 3 days and STAY better. They don't relapse on meds. The most common reason for initially doing well on the doxycycline and then getting worse again is immune mediated polyarthopathy. That is treated with immunosuppressants like prednisone. I would get a second opinion. I wish Max a speedy recovery!

My dog's limping on Lyme meds, but tests are negative. Second opinion?

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