My dog has Myasthenia Gravis. What causes vomiting and other treatments?

Question

Hello dear, After so many test, the vet diagnosed that my dog has Myasthenia gravis. He used mestinon for 3 months and it didn't work. Since Friday he started new medication (Azathioprine, prednisone) 25 mg of each, every day. But he has still problem. He vomits every day a very tick jelly mocus. And he cannot close his eyes. Please give me some information about the diseas. Is there any other treatments for the myasthenia gravis? Pet's info: Dog | Mixed Breed Medium (23 - 60lb) | Male | 2 years and 6 months old | 20 lbs

John C. Gicking, DVM, DACVECC · Accepted Answer

Thank you for using Petco Pet Education Center, formerly Petcoach! Myasthenia gravis is an immune attack against the receptors to acetylcholine on cells. Medications that are used to treat this disease are used to increase the relative amount of acetylcholine that remains at the nerve-cell interface and others are used to try and decrease the immune attack against the receptors on the cell. Mestinon decreases the destruction of acetylcholine and therefore increases its activity of the acetylcholine. This usually helps with muscle weakness. Prednisone and azathioprine are immune suppressant drugs. Myasthenia gravis may occur as a primary (idiopathic) disorder or maybe secondary to other diseases such as cancers. If another cause is discovered (such as cancer) then then you need to treat the primary condition to try and resolve the myasthenia gravis. Unfortunately, many pets with myasthenia gravis can still have signs of esophageal dysfunction. Megaesophagus (dilation and weakness to the esophagus) commonly occurs and sometimes may not resolve even with otherwise effective treatment. This leaves many pets with myasthenia gravis at risk for developing aspiration pneumonia due to chronic regurgitation. A veterinary neurologist is often helpful to have involved in these cases.

My dog has Myasthenia Gravis. What causes vomiting and other treatments?

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