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Is it safe to give my dog Benadryl with Apoquel for itching?

Updated On September 23rd, 2025

Pet's info: Dog | Chihuahua | Female | spayed | 4 years and 7 months old | 8 lbs

Dove takes apoquel for itching when it gets bad. I figured its 1/2 pill every 24 hrs. It doesnt seem to be helping as the pill wears off becuase we give both dogs half a pill for dinner every night. So is it safe to give her benadryl to help with the itching as well?

1 Answer

Most Helpful Answer

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Answered By Rebecca, DVM

Veterinarian

Published on July 1st, 2018

Thanks for using Petco Pet Education Center, formerly Petcoach. Yes. Benedryl can be safely used in conjunction with apoquel. But please give her vet a call to discuss her medications- they may want to increase her apoquel dose or switch to a different medication if it isn’t effective currently.

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