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Can my dog safely take Apoquel while using cyclosporine eye drops?

Updated On September 23rd, 2025

Pet's info: Dog | Shih Tzu | Male | neutered | 10 years and 9 months old | 25 lbs

My vet is on vacation but I have a question about the new meds my vet prescribed my dog. My dog takes cyclosporine eyedrops ( 1 drop per eye twice a day) for dry eye. His vet also prescribed Apoquel for his skin allergy because he can no longer take steroids due to being diabetic. Since Cyclosporine and Apoquel taken together have adverse reactions will taking the Apoquel while he is on cyclosporine EYEDROPS be harmful?

2 Answers

Most Helpful Answer

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Answered By Ana M, DVM

Veterinarian

Published on June 20th, 2018

Thank you for submitting your question regarding Jersey. I do not believe it would be a problem from him be on topical cyclosporine eye drops while taking Apoquel. The eye drops would have minimal, if any, systemic absorption. I do not currently have a patient of mine on both medications, but would be willing to prescribe them together. However, if you still have concerns you can call Zoetis, the manufacturer of Apoquel. I hope this information helps!

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    Answered By Justin Plunk, DVM

    Veterinarian

    Published on

    Hi, thanks for using Petco Pet Education Center, formerly Petcoach! Jersey seems to have quite a few things to deal with. While I can't say for sure, it is likely his Veterinarian has considered the costs and benefits of the simultaneous administration of his medications while prescribing them. The amount of cyclosporine that will be absorbed systemically are likely to be much lower than therapeutic doses of the oral version. Continue administering the medication as prescribed by your veterinarian, and call them at the earliest convenience for clarification. If you notice an issue with Jersey in the mean time such as loss of appetite or lethargy, have him check by a veterinarian immediately. Hope this helps!

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