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My dog had Lyme and kidney issues. What's her prognosis after doxy?

Updated On September 23rd, 2025

my dog tested positive for lyme and kidney problems. her creatanine level was 3.0 and bun was also high. there was no protein in her urine. My vet recommended a 4 week course of doxy which she has completed. She is doing well, eating, playing, and interacting with us. What is her prognosis? I am unclear what to expect going forward?

2 Answers

Most Helpful Answer

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Answered By Jacqueline Nobles, DVM, DACVECC

Veterinarian, Board-Certified Emergency/Critical Care Specialist

Published on May 28th, 2018

Hello, While we know that Lyme disease can cause kidney disease, we cannot assume that the Lyme disease is causing kidney injury in this case. Many pets will test positive for Lyme disease on a screening test if they have been exposed to the disease. However, exposure does not equate to clinical infection in every case. In order to determine if Lyme disease is causing kidney injury, we need to measure antibody levels in the blood, ultrasound kidneys, and obtain a kidney biopsy. Without this information, it will be difficult to give a prognosis. I would advise you to follow up with your veterinarian to discuss recheck kidney values, abdominal ultrasound and urinalysis.

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    Answered By Dr. Strydom, DVM

    Veterinarian

    Published on July 23rd, 2017

    Yes, unfortunately it is possible. It is easy to diagnose kidney failure with a simple blood test and urinalysis. Instead of wondering, I would recommend having the testing done. That way you will know what you are dealing with. Some dogs are infected with Lyme disease (a spirochete organism) but do not show symptoms until months or years later, and some never show signs. Some dogs are in fact harmed by the long-term presence of an infectious organism in their bodies. The immune system is constantly active in its attempt to remove the organism, and over time these complexes of antibodies may deposit in the kidney and cause damage. Is Sam taking Doxycycline? If not, I would suggest you speak to your vet about getting a long course of this antibiotic. And I would also have the blood and urine testing done. I hope this helps. Best wishes to you and Sam.

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