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Is it safe to give my dog Sildenafil and Pepcid at the same time?

Updated On September 23rd, 2025

Pet's info: Dog | Chihuahua | Male | neutered | 14 years old | 5.4 lbs

Hi. Is it safe to give Sildenafil and pepcid at the same time? Thank you!

1 Answer

Most Helpful Answer

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Answered By Linda G, MS, DVM

Veterinarian

Published on February 26th, 2018

Hello. There are no reported problems administering these 2 medications together, although there is a warning about administering Sildenafil with a similar medication cimetidine ( Pepcid is famotidine ). So just to be sure, I would separate these 2 medications by at least 30 minutes, ideally would be 1-2 hours. Since famotidine can alter the ph of the gastric mucosa & thus potentially affect the absorption of other medications, I would give the sildenafil first. Thanks for using Petco Pet Education Center, formerly Petcoach.

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