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Why is my cat with kidney disease losing weight and antibiotics failing?

Updated On September 23rd, 2025

Pet's info: Cat | Mixed Breed | Male | neutered | 7.8 lbs

We adopted a stray cat, we have no prior knowledge of his history. Since we adopted him, he’s had to have teeth extracted. Additionally he’s has chronic respiratory issues and hasn’t been more than 10lbs. Despite having acute renial failure, our vet has been allowing us to give him antibiotics once a month to fight the respritory infection. In the last 4 weeks he has lost serious weight he was 9.4 lbs now he is 7.8lbs. The antibiotics are no longer working. We need help figuring out whats wrong

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1 Answer

Most Helpful Answer

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Answered By Christie Long, DVM

Veterinarian, Certified Veterinary Acupuncturist

Published on February 22nd, 2018

Renal failure often causes cats to lose weight. The waste products that build up in the blood because the kidneys can't properly eliminate them cause nausea and gastritis (inflammation in the stomach) and sometimes even ulcers in the mouth. Talk to your vet about trying some medications to manage these conditions - either omeprazole or famotadine are often helpful, as well as the anti-nausea drug Cerenia. Also the drug mirtazipine can be used to help stimulate his appetite. Unfortunately it sounds like he has multiple problems that may be difficult to manage concurrently. I'd also consider running a bacterial culture of the nasal discharge to try to focus the antibiotic therapy and ensure that an effective drug is being used.

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