What cisapride dose for my cat with chronic constipation & megacolon?

Question

What is the maximum dosage of cisapride for a 19 pound cat with chronic constipation and suspected megacolon. Pet's info: Cat | Mixed Breed | Male | neutered | 7 years and 11 months old | 19 lbs

Megan, DVM, CVA · Accepted Answer

From Plumb's Veterinary Drug Handbook "For chronic Constipation (e.g. megacolon): In combination with a stool softener (author recommends lactulose at a starting dose of 2-3 mL PO three times per day; then adjust as needed) and a bulk agent (e.g. psyllium or pumpkin pie filling) cisapride is given initially at 2.5mg (for cats up to 10 lbs) or 5mg (for cats 11 pounds or heavier) three times daily, 30 minutes before food. Cats weighing greater than 16 pounds may require 7.5mg" So in short, Merlin may require a 5-7.5mg dose three times per day. Before changing the dose, I would talk to the prescribing veterinarian about Merlin. I would discuss whether or not he needs a stool softener and whether he needs to be on canned pumpkin daily. Depending on how regulated he is or how constipated he is, he may need different things. If he hasn't had a bowel movement for awhile, he will likely need an enema. I have also found that cats with megacolon respond REALLY well to the prescription diet Royal Canin GI fiber response. Talk to your vet as they can likely order it for you or write a written prescription for you. I hope this helps!

What cisapride dose for my cat with chronic constipation & megacolon?

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