How to help my dog with liver disease, Cushing's, and weight gain on phenobarbital?

Question

Dog gained 5 pounds from 10 pounds, takes phenobarbital, and blood test showed liver disease, and cushings. I added meletonin, sam e, milk thistle, and childrens vitamins, and am reducing her phenobarb, is thrre more that i can do? She is a pomeranian chiwauwau mix. Pet's info: Dog | Pomeranian | Female | spayed | 9 years and 2 months old | 15 lbs

Dr. Heidi DVM, CVA, CCRT, CVTP, CVSMT, CVCH · Accepted Answer

I'm so sorry that Molly is having these problems. I am attaching a handout below on Phenobarbital which may give you more information on her situation. https://www.veterinarypartner.com/Content.plx?P=A&S=0&C=0&A=522 Phenobarbital can certainly increase a dog's appetite, so you have to make sure that they are not eating more when they are receiving Phenobarbitial so they don't gain weight. Phenobarbital will also increase liver enzymes on a blood panel. In order to determine liver function, we need to do an additional test called a Bile Acid Profile. If Molly's Bile Acid Profile is abnormal, then her liver is not working properly and decreasing her dose of Phenobarb may be a good idea, but you will need to discuss with your veterinarian how to do that safely and if you need to add another anti-convulsant medication to prevent her from having seizures again. Milk Thistle and Same-E are my 2 favorite liver support supplements, so I think you have her liver well supported with those supplements. I have seen good results in decreasing liver enzymes with those 2 supplements. Good luck! I hope that was helpful. Thanks for using PetCoach.

How to help my dog with liver disease, Cushing's, and weight gain on phenobarbital?

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