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My spayed puppy is too active post-surgery. Can Benadryl calm her?

Updated On September 23rd, 2025

Pet's info: Dog | Goldendoodle | Female | spayed | 7 months and 24 days old | 32 lbs

My female dog 7 months old was fixed two days ago. She’s a very active dog and is feeling better and having a hard time with staying calm and not running around. In the crate, while she does fine at night time, she is being wild and I’m worried the crate is even worse for trying to keep her run around. Would it be appropriate to give her Benadryl to keep her sedated for the next few days? She is 7 months old and weighs 32 pounds. Pic for cuteness.

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1 Answer

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Answered By Jenny, DVM

Veterinarian

Published on January 20th, 2018

Benadryl is fine and safe to give however if she isn’t calmer out of her kennel you can let out when you are there to supervise her. As long as she is. It running around playing fetch and chasing things or jumping up and down a bunch, then she will be fine. Benadryl can be given twice a day safely and 25 mg is appropriate

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