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My dog's itchy rash on stomach, legs, armpits. Benadryl not working?

Updated On September 23rd, 2025

Pet's info: Dog | Mixed Breed Medium (23 - 60lb) | Female | spayed | 3 years and 9 months old | 55 lbs

My dog has a rash on her stomach, legs and armpits. It’s red and blotchy and very itchy, not raised at all. I was instructed by the vet to be giving her Benadryl for seasonal allergies which I started a few days ago once her itching became worse. I’m not sure when the rash appeared and I’m not sure if it is caused by the Benadryl. I do not believe it was since she has been itching badly for a while now. I have checked her for fleas and tics and all of that and she does not appear to have any.

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1 Answer

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Answered By Kevin Sanada, DVM

Veterinarian

Published on January 17th, 2018

The spots where the rashes are definitely fit with seasonal environmental allergies. They may not have been there before, but would not be due to the Benadryl. It's more likely that it's a progression of the allergies and a sign that the Benadryl is not working well. Dogs tend to not be helped by certain antihistamines, but may be helped better by others. Luckily there are a few alternatives that can be bought over the counter. I recommend calling you veterinarian and asking if they could suggest another antihistamine. As long as they have no other concerns with Riley, they should be happy to give you an alternative. If the second antihistamine doesn't work and you still notice the rash/itching, then he will likely need a recheck exam and stronger medication. One thing you can do for the rash and itchy skin, is give a bath with cool water using an oatmeal or aloe shampoo. You can get these shampoos at the pet store. I hope that helps and Riley gets better soon.

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