My senior dog feels better, but her WBC/RBC counts are worse. Why?

Question

Our 13 year old cocker spaniel has been healthy most of her life. On 12/26 she was vomiting and had diarrhea so we took her to our vet. Her white blood count was 44.68 K/ul. Red blood count was 6 M/ul. She was prescribed Bactria 22.7 for 2 weeks. Today she is physically doing much better (good appetite, walking good, no problem going to the bathroom etc) but her WBC is 53.51 and RBC is 4.95. Several of the other blood work results are normal. What’s your thoughts on this? Pet's info: Dog | Cocker Spaniel | Female | spayed | 13 years and 4 months old | 21 lbs

Jenny, DVM · Accepted Answer

With a white count that keeps getting higher despite antibiotics I would be concerned there is cancer hiding somewhere. An ultrasound would be my next test as it can look at the intestine, lymph nodes, liver and spleen. The spleen makes the red blood cells, and if it has a tumor then that can cause that count to drop. An immune disease can also cause a low red count.

My senior dog feels better, but her WBC/RBC counts are worse. Why?

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