Why is my cat's Depo-Medrol asthma shot wearing off so quickly?

Question

Hello, my cat Whiskey has chronic cough, possibly asthma. He had a shot of depo-medrol in Apr 2016 and was cough free for 6 weeks. He got another shot Aug 28 2017 and was cough free for 8 weeks, the latest shot was on Oct.28 2017 and Nov 24 he already has a cough. Why would effect of the last depo-medrol shot wear out so quickly this time? First two were given subQ at one clinic and the last one intramuscular at a different clinic if it matters. Thank You. Pet's info: Cat | Domestic Mediumhair | Male | neutered | 9.5 lbs

Dr. Dayna, DVM, CVA · Accepted Answer

I wonder if the dosing they have may have been different. There is a large dosing range for Depomedrol. It is also possible that his disease is becoming worse and that the injection may not work as well as it used to. I tend to use oral dexamethasone tablets for my asthmatic cats, I like to be able to increase or decrease the dose based on how the kitty is doing. I hope this helps! Thank you for using Pet Coach.

Why is my cat's Depo-Medrol asthma shot wearing off so quickly?

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