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Why is my 4-week-old puppy's lymph node swollen after medication?

Updated On September 23rd, 2025

Pet's info: Dog | Mixed Breed | Male | unneutered | 1 month and 1 day old

My 4 week old puppy had a small wound in his back and without exams to be sure it was parasites the vet gave an injection called Trisullak (Sulfadiazine, Trimethoprim and Tylosin) and a third part of a pill called Septra. After 2 hours i saw a swollen limph node in his neck, wich I suppose after searches to be an allergic reaction of sulfa drugs. It's been 4 days and the node is getting bigger. I can't go back to this vet, and no other option here in a small town in the Philippines. Help please!

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1 Answer

Most Helpful Answer

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Answered By Daniel Fonza, DVM

Veterinarian

Published on November 24th, 2017

Hi there and thank you for using Pet Coach to address your concern. That is quite the large bulge on poor Baby's neck! I would not expect the sulfa drug that was given to Baby to cause this focal swelling of a single lymph node. I am more suspicious of this being puppy strangles. This can cause the lymph nodes to become markedly enlarged and the face swollen as well. Unfortunately by advice for you is to take him to the veterinarian as most likely the treatments that need to be administered should be done by a veterinarian. This could also be an abscess in this area, in which case needs to be drained by a veterinarian. I hope this helps guide you in the right direction. Please let me know if you have any other questions.

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