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Should I skip my small puppy's 12-week vaccine due to mom's immunity?

Updated On September 23rd, 2025

Pet's info: Dog | Saint Bernard | Male | unneutered | 2 months and 7 days old | 31 lbs

I have been reading a lot of conflicting info on puppy vaccinations and their ineffectiveness until a later age due to the mother passing on immunity. I hate to over vaccinate. Seeing as he already had a shots at 5 weeks and the 5 way at 9 weeks Can I hold off and just give him the 5 way again at 16 weeks and skip the 12 weeks shot. He is already on the smaller side of his litter, I just don’t want to overload him. Thanks in advance

1 Answer

Most Helpful Answer

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Answered By Dr. Elizabeth

Veterinarian

Published on November 13th, 2017

I would not advise to skip the 12 week set. As the antibodies wear off, he will lack immunity. The idea is that the vaccine will stimulate his immune system. As long as he has mom's antibodies, his immune system will not fully react to the vaccine. The reason they get so many vaccines is that you are trying to make sure he has vaccines on board during the time of the shifting between his mom's antibodies and his own immune system taking over. You will not over vaccine him. Its better to be safe than to risk Parvo. The main time I worry about vaccines is when dogs are getting 3 or more vaccines at a time. Smaller dogs and certain breeds are more prone to vaccine reactions. So if anything, separate out vaccines so that he is not getting a bunch all at once. I hope this helps and congratulations on adding Brady to your family!

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