My cat meows nightly. Are cat sedatives like Chlorpheniramine safe?

Question

Misty hollers every night all night and keeps me awake. I have tried ignoring and also feliaway which doesnt work. My vet prescribed Chlorphenirimine a anthestimine for sedation today. Read online that a side effect on cats is inability to urinate which worries me. Is this safe? Also read that the herb Valerian works . What are your thoughts and any other sedative work and is safe? Thank you. Pet's info: Cat | Domestic Longhair | Female | 4 years and 7 months old | 15 lbs

Lauren Barry, BVSc, MRCVS, DVM · Accepted Answer

My first thought is whether Misty has been spayed/ fixed or not as she may be hollering for a mate. If she is spayed, then other sedatives / anxiety medicines may be effective to help curb her night time behavior. I dont have a lot of personal experience using chlorpheniramine in cats, but this class of antihisthamine is relatively safe. The drugs that I may consider dispensing would be gabapentin or amitryptilline. These are both prescription medicines. I have found minimal benefit in herbal remedies in cats - valerian would not be very effective. Royal Canin make a diet called "Calm" which can help with anxiety/ stress behaviors as well.

My cat meows nightly. Are cat sedatives like Chlorpheniramine safe?

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