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Is 100mg Trazodone safe for my 20lb puppy with separation anxiety?

Updated On September 23rd, 2025

Pet's info: Dog | Mixed Breed Medium (23 - 60lb) | Female | unspayed | 4 months and 9 days old | 20 lbs

My dog was prescribed 100mg of Trazodone as needed for separation anxiety/sedation. I've been reading about normal dosages in dogs, and this seems like quite a bit to start off with. Is 100mg too much for a 20 lb puppy?

1 Answer

Most Helpful Answer

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Answered By Lauren Jones VMD

Veterinarian

Published on October 26th, 2017

The dose range for Trazodone in dogs is very wide. For use as needed, published doses range from 2.2-14 milligrams per kilogram (mg/kg) of body weight per day. Based on her current 20 pound body weight, Luna has been prescribed 10.1 mg/kg, which is a perfectly acceptable dose. There are limited studies of the use in Trazodone in dogs, but it seems to be a very safe medication and anecdotal doses have been safely reported in excess of the published doses mentioned above. Since Luna is still a young, growing puppy, expect her dose to increase over time as she gets older and bigger. I hope this helps and that all goes well in managing Luna's separation anxiety!

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