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Dog liver issues: Why are Destolit and Synulox making him worse?

Updated On September 23rd, 2025

Pet's info: Dog | Mixed Breed Medium (23 - 60lb) | Male | unneutered | 9 years and 3 months old | 30.6 lbs

Hello my 8 year old lab has recently been taken ill with liver issues ? He's prescribed Destolit and Synulox ? These have seemingly made him significantly worse.... I need guidance?

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1 Answer

Most Helpful Answer

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Answered By Jenna Beyer, DVM, MBA, cVMA

Veterinarian, Certified Veterinary Acupuncturist

Published on October 9th, 2017

Destolit is a medication to try to stimulate movement of bile out of the gall bladder. Synulox is an antibiotic. These can be used if the veterinarian thinks that there may be an infection in the body or sludge in the gall bladder causing Billy's illness. A common side effect of synulox is vomiting. You can try giving it with food to avoid causing nausea. However, the worsening of his previous symptoms may indicate that the medications are not helping and that his disease is progressing. I would recommend that you discuss this with your vet to see if there is another treatment or other diagnostics that can be run to see what else can be done.

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