Petco Text Logo
Petco Pet Logo

Cat's flea treatment not working. Can I safely apply Frontline now?

Updated On September 23rd, 2025

Pet's info: Cat | Domestic Longhair | Female | spayed | 10 lbs

I place Sentry Plus flea medication on my cats last Wednesday. The medicine does not seem to be working. Can I safely use Frontline now or do I need to wait one month to apply it?

1 Answer

Most Helpful Answer

Image profile

Answered By Jenna Beyer, DVM, MBA, cVMA

Veterinarian, Certified Veterinary Acupuncturist

Published on October 2nd, 2017

Since both Sentry and Frontline use the same active ingredient (fipronil) it is unlikely that you will see better protection switching to the Frontline. You will need to choose a product with a different ingredient, like Advantage or Revolution or a Seresto collar. If you choose to use another topical, I would recommend bathing your kitty today to remove any remnants of the Sentry, and wait 3 days to apply the next topical. It is important to wait after bathing so that the natural body oils have time to coat the skin to ensure adequate absorption. You do not need to wait or bathe to use a Seresto collar.

Vote icon

1Pet Parents found this answer helpful

image
Have A Vet Question?

Book an appointment with the pros – our expert vets are here to help.

Sponsored