My dog accidentally took double Keppra and Zonisamide. Is it serious?

Question

My dog takes 750mg Keppra and 400mg zonisamide twice a day. Tonight she got her pills twice by accident 90 minutes apart. She seems fine but is this serious? Pet's info: Dog | Mixed Breed Large (61lb +) | Female | spayed | 9 years and 7 months old | 88 lbs

Rodrigo Roca, DVM · Accepted Answer

Hello, Keppra has a wide safety margin and very high dosages have been reported to cause increase salivation. The zonisamide is 2 times the high end of normal, but not near the dose where it could be dangerous. You may note that Molly is sedate, lethargic, she may have some vomiting or wobbly walk. You should contact your veterinarian in the morning to see if they want you to continue normal dosing times or if you should change the timing. Monitor for any overly sedate behavior or obtundation and contact your emergency veterinarian if you note any. Best of luck and hope this helps.

My dog accidentally took double Keppra and Zonisamide. Is it serious?

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