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Is 5mg prednisone every other day safe for my dog long-term?

Updated On September 23rd, 2025

Pet's info: Dog | Mixed Breed Large (61lb +) | Female | spayed | 70 lbs

Sasha was diagnosed with spondylosis which caused limping and difficulty getting up. She was treated with tramadol, neurotin &prednisone 20 mg/ day for 2 weeks. She had a remarkable recovery but we are trying to wean her off prednisone. She is on prednisone 5mg every other day and does fine, along with neurontin and Adequan shots. But, every time she goes more than 2 days off of prednisone, she starts to limp again. How long can she stay on prednisone 5mg every other day? Isn't this harmful?

1 Answer

Most Helpful Answer

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Answered By Anna M., DVM

Veterinarian

Published on September 25th, 2017

Hello, and thank you for using Petco Pet Education Center, formerly Petcoach. This is a great question. Long-term administration of *any* medication will have pros and cons, but in my opinion if the prednisone is keeping Sasha comfortable, she can definitely stay on it long-term. Side effects and concerns associated with prednisone are all dose-dependent, and Sasha's dose of 5mg every other day is an extremely low and safe dose. I would be very comfortable keeping her at this dose long-term, and would not expect any harm to come from it. We have a long list of conditions that are treated with prednisone, and I have many patients who must be on prednisone for life. These patients tend to do great, often on MUCH higher doses than Sasha is receiving. As long as your vet is comfortable with you keeping her on prednisone, go for it! Hope this helps! Feel free to request a consultation if you'd like to discuss Sasha's management in more detail.

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