My dog on Trilostane for Cushing's. Can I stop it due to side effects?
Updated On September 23rd, 2025
Pet's info: Dog | Parson Russell Terrier | Male | neutered
my dog is on trilostane 30 mg a day for cushings but i think it is making him unwell-he wasnt unwell before just had a bit of a pot belly and this belly has got bigger..he has no other symptoms..if i stop the Trilostane after two weeks of it will he be ok i mean no bad effects coming off it?
3 Answers
Most Helpful Answer
Published on November 14th, 2016
It's never a good idea to stop or make any dosing changes in a prescription medication without your vet's input, so I would definitely recommend giving him/her a call to discuss your concerns before you change anything. In general, I can tell you that if your dog has symptoms like lethargy, vomiting or diarrhea, or not wanting to eat, this may be a sign that the trilostane dose needs to be reduced. So this is definitely cause for concern - I would call your vet today to let them know. They may recommend having Max come in for blood work to check his cortisol levels - this will help determine what needs to be done regarding his medication.
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Related Answers from Veterinarians
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Published on
No, I would not stop the trilostane without speaking to your vet first. I would give the vet a call with your concerns, as leaving Max without medication will cause the symptoms of Cushing's to return. You and your vet can discuss if the medication needs to be stopped. It's never recommended to make medication decisions about your pet without talking to your vet first, as you may accidentally do harm to your dog.
0Pet Parents found this answer helpful
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Published on August 28th, 2018
There is no one Trilostane dose. A veterinarian will always prescribe a dose individual to the animal. This will depend on the clinical exam in combination with the blood test results and any other information the veterinarian gathers. Medications have a dosage range. Dosages are adjusted, and sometimes dosages also fall outside the range depending on the case. Dosages are per dog and not according to weight. 3mg Trilostane twice daily is lower than the dose that used to be given and a tad higher than the usual dose. You should ask your veterinarian why he chose this dosage, and he should be able to give you the reason.
1Pet Parents found this answer helpful
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