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My dog on Trilostane for Cushing's. Can I stop it due to side effects?

Updated On September 23rd, 2025

Pet's info: Dog | Parson Russell Terrier | Male | neutered

my dog is on trilostane 30 mg a day for cushings but i think it is making him unwell-he wasnt unwell before just had a bit of a pot belly and this belly has got bigger..he has no other symptoms..if i stop the Trilostane after two weeks of it will he be ok i mean no bad effects coming off it?

2 Answers

Most Helpful Answer

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Answered By Jennifer Summerfield, DVM CPDT-KA

Veterinarian, Certified Dog Trainer

Published on November 14th, 2016

It's never a good idea to stop or make any dosing changes in a prescription medication without your vet's input, so I would definitely recommend giving him/her a call to discuss your concerns before you change anything. In general, I can tell you that if your dog has symptoms like lethargy, vomiting or diarrhea, or not wanting to eat, this may be a sign that the trilostane dose needs to be reduced. So this is definitely cause for concern - I would call your vet today to let them know. They may recommend having Max come in for blood work to check his cortisol levels - this will help determine what needs to be done regarding his medication.

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    Answered By Dr. Melanie, BVSc MS

    Veterinarian

    Published on

    No, I would not stop the trilostane without speaking to your vet first. I would give the vet a call with your concerns, as leaving Max without medication will cause the symptoms of Cushing's to return. You and your vet can discuss if the medication needs to be stopped. It's never recommended to make medication decisions about your pet without talking to your vet first, as you may accidentally do harm to your dog.

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