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Dog lymphoma: What are the signs of end-stage and poor quality of life?

Updated On September 23rd, 2025

Pet's info: Dog | Golden Retriever | Female | spayed | 8 years and 8 months old | 75 lbs

Am LVT w/20 yrs XP. Have a Golden w/lymphoma multinodal, nodes are re-growing on pred. Is she entering end-stage? Can't find a good website to help me know what to watch for to know It's Time, am all about QOL. She has been asymptomatic other than enlarged nodes, and pred side effects.

1 Answer

Most Helpful Answer

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Answered By Ricardo Fernandez, DVM

Veterinarian, Veterinary Oncology Resident

Published on August 23rd, 2017

Hi there! Thanks for using Petco Pet Education Center, formerly Petcoach! This is a common question I encounter as I only see cancer patients and lymphoma is very common in my practice. Prednisone is good for lymphoma though as you are noticing, lymphoma will eventually progress, as noted by peripheral lymph node enlargement. Normally, lymphoma will not cause clinical signs for some time until it enters more of the end stage. Lymphoma is not typically a painful disease and it is more of a debilitating disease. For this reason, what you will notice at the end is clinical signs such as lethargy, decreased appetite and Brandi just not being interested in the normal things that she enjoys. The median survival time of dogs with multicentric lymphoma just on prednisone is about 2 to 2 and 1/2 months. Usually I tell my clients that the time to consider humane euthanasia is when they are not doing 3 out of their 5 favorite things. Good luck with your girl!

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