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What sedatives are safe for an anxious small dog flying on a plane?

Updated On September 23rd, 2025

Pet's info: Dog | Mixed Breed Small (up to 22lb) | Male | neutered | 7 years and 3 months old | 12.5 lbs

What sedative is recommended for a 12 lb. terrier mix (very aggressive and a barker) to fly from CA to FL?

1 Answer

Most Helpful Answer

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Answered By Jeffrey Milner

Veterinarian

Published on August 21st, 2017

Several different drugs are available for this purpose. The drugs I use the most often for this sort of situation include trazodone, alprazolam (Xanax), and acepromazine. The last of these drugs will not provide any relief for anxiety for Muttley, instead it will simply tranquilize him. The other two will have both sedative and anti-anxiety activity. Discuss the situation with your veterinarian and determine which option you believe will be best. Hope this works out. If your pup is going to be travelling in the cabin, for the sake of the other passengers the use of the tranquilizer may be the best option.

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