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Can creatine in joint chews raise creatinine in dogs with kidney disease?

Updated On September 23rd, 2025

My dog Heidi was diagnosed with chronic renal failure a couple of years ago-her creatitine levels were starting to creep above normal- azodyl and epikitan have everything back to normal levels now but people at my vet office urged me to put her on Synovi G4 dog chews for joint support- I only gave her two ;one a day) till I read one ingredient is 250 mg of creatin-My vet is out of town - I have a feeling this will raise her creatitine level- am I right?

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Answered By David Darvishian

Veterinarian

Published on August 4th, 2017

Hi and thanks for using Petco Pet Education Center, formerly Petcoach! Sorry to hear about Heidi but it sounds like the treatment plan is working great. I'm not sure we really know if creatine truly affects creatinine levels and kidney function but there is evidence out there suggesting that people with kidney dysfunction or problems shouldn't take creatine supplements. To be safe I would find an alternative product to use to address her joint problems. There are many supplements out there and I like the Nutra Max Laboratory products. These include Cosequin, Dasuquin, and other products. To my knowledge they don't contain creatine. So just to be safe, I would advise holding off on what you have and instead switch to another option. I like Nutra Max products because all of their supplements are produced under pharmaceutical grade conditions and all of their products are tested to make sure they contain what the label says. You can get them over the counter at the larger pet stores, at your veterinarian, or online. Good question, good attention to detail. Good Luck!!

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