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What is the safe and correct Benadryl dosage for my 50-pound dog?

Updated On September 23rd, 2025

Pet's info: Dog | Pit Bull Terrier | Female | spayed | 7 months and 7 days old | 48 lbs

How much Benadryl do you give a 50lb dog

3 Answers

Most Helpful Answer

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Answered By Destini R. Holloway, DVM

Veterinarian

Published on July 24th, 2017

The dosage is 1 mg per lb, so a 50 lb dog would get 50mg of Benadryl once every 12 hrs. Only pets with no hx of underlying heart disease or drug interactions can safely have Benadryl. You should always check with your vet on if this medication is appropriate for your pet, based on her history. Best wishes and take care.

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    Answered By Dr. Strydom, DVM

    Veterinarian

    Published on December 23rd, 2019

    The dose of Benadryl is 1mg per pound of body weight. If he is 20 pounds he needs about 20mg of Bendaryl. One adult capsule is 25mg so he can have that. If all you have is liquid you will have to give him quite a bit. The liquid is only 2.5mg/ml so he will need 10ml which equals 2 teaspoons.

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    Answered By Jennifer Summerfield, DVM CPDT-KA

    Veterinarian, Certified Dog Trainer

    Published on August 29th, 2020

    It's a bit easier if you think of the dose as being 1 mg per pound of body weight. :) For my clients, I usually recommend rounding down to the nearest whole tablet size from there. So for a 71 pound dog, I would generally suggest giving 50 mg (which would be two 25 mg tablets).

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