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My dog has car anxiety. What can I give him for a road trip? Benadryl?

Updated On September 23rd, 2025

Pet's info: Dog | Mixed Breed Small (up to 22lb) | Male | neutered | 9 days old | 14.5 lbs

My dog has separation anxiety and gets anxiety in the car and in crates. I am taking a road trip with him from South Carolina (where I live) to visit my family back home in New York. I wanted to know if there was anything I can give him for the car ride? I was told children's Benadryl cut in half is a good option. He is a jack russell/chihuahua mix and about 14.5lbs

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2 Answers

Most Helpful Answer

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Answered By Jennifer Summerfield, DVM CPDT-KA

Veterinarian, Certified Dog Trainer

Published on July 18th, 2017

Benadryl is generally quite safe for dogs so it's unlikely that this would cause any harm; however, it rarely does much to help with anxiety in my experience. A better option would be to talk to your veterinarian about prescription anti-anxiety medication such as alprazolam or trazodone - these medications are much more effective for anxious pets, and can be used as-needed for car rides or other situations that may cause stress :)

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    Answered By Rebecca, DVM

    Veterinarian

    Published on

    I would recomend a vet visit before your trip. There are very effective prescription medications that can help Willie with his anxiety and car sickness. If he already has anxiety issues and this trip is a brand new thing for him then I suspect benedryl is not going to be nearly enough to help either issue. Good luck and safe travels.

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