Can my dog safely take Rimadyl and Trazodone at the same time?

Question

Are there any drug interactions between Rimadyl and Trazodone? My german shepherd was spayed two days ago and was given Rimadyl for pain and inflammation. She is also prescribed trazodone for anxiety. I was planning on giving her trazodone tonight to calm her down before all of the trick-or-treaters come knocking on our door. Can I safely combine the drugs? Pet's info: Dog | German Shepherd | Female | spayed | 1 year and 7 months old

Andrea M. Brodie, DVM · Accepted Answer

I cannot find any interaction reports for Trazodone with carprofen (Rimadyl), however there are reports that Trazodone has interactions with Ibuprofen, a similar class of NSAID. This reports that either increases toxicity of the other by added drug effects. Check with your veterinarian on whether he recommends giving the two together. There maybe less toxic effect by giving the Rimadyl in the morning and the Trazodone in the evening. However this is for your vet to decide. If you cannot reach your veterinarian I suggest not to give the Trazodone tonight and keep the dog in a room where she is not likely to be bothered much by trick or treaters.

Can my dog safely take Rimadyl and Trazodone at the same time?

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