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How soon does Depo Provera in dogs prevent pregnancy or mating?

Updated On September 23rd, 2025

Pet's info: Dog | Canaan Dog | Female | unspayed | 11 months and 2 days old

Depo provera 150mg injection for female dogs how time it needs to work for preventing mating or pregnancy?

1 Answer

Most Helpful Answer

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Answered By Destini R. Holloway, DVM

Veterinarian

Published on September 23rd, 2016

The Depo Provera (Medroxyprogesterone acetate) drug is effective immediately and can be used to regulate a pets reproductive cycle when given IM every 5 months. It has to be strictly monitored by your vet. Although I will say that most vets won't use this drug because it has some serious possible side effects including iatrogenic: Diabetes Mellitus, Hypothyroidism, and Pyometra. I myself won't use or recommend this drug in any of my patients. And besides paying the female, there are no alternative ways to prevent pregnancy in dogs that I am aware of at this time.

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