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Why is my dog twitching after topical flea and tick medicine?

Updated On September 23rd, 2025

Pet's info: Dog | Shih Tzu | Male | neutered | 2 years and 5 months old | 11 lbs

Yesterday, we gave Simba Parastar Plus for dogs for flea and tick (topical medication on his back). This was the first time we've ever used this brand or a topical medicine on him. Last night he was unable to get comfortable or sleep b/c he kept twitching whenever he closed his eyes. We gave him a bath to scrub off the medication, thinking that's what might caused it. He is only able to sleep when we pet him, when we stop he starts twitching/jerking and wakes up. No other symptoms. Any ideas?

1 Answer

Most Helpful Answer

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Answered By Lauren Jones VMD

Veterinarian

Published on June 13th, 2017

Poor Simba! The twitching and irritability that he was showing you certainly sound like a reaction to this topical flea and tick medication. You did the right thing by bathing him to remove as much of the medication as possible. However, since he is still twitching and irritable, Simba should go to his vet for evaluation. There are muscle relaxers that can help with the twitching and steroids if an allergic or inflammatory reaction is diagnosed, both of which will likely make him far more comfortable. In the future, I typically recommend sticking with K9 Advantix II, Nexgard or Bravecto, but talk to your vet about their recommended products. I hope that all goes well!

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