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Is amoxicillin safe for my dog's liver and kidneys long-term?

Updated On September 23rd, 2025

Pet's info: Dog | German Shepherd | Male | 1 year and 3 months old

For mouth ulcer caused by tongue touching incisor and canine tooth vet prescribed amoxicillin potassium clavulanate 625mg twice daily for 10 days and 3 months before he was having wound on his hind leg which is caused by continuous licking of leg at that time also doctor prescribed 625mg amoxicillin potassium clavulanate so my question is frequently going on for this medication will it going to cause harm to his any organ liver or kidney at present or in future as I am scared of antibiotics

2 Answers

Most Helpful Answer

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Answered By Ann Dion, DVM

Veterinarian

Published on March 24th, 2017

Hi there. Amoxicillin/Clavulanic Acid is a very safe antibiotic and is not very hard on the kidneys and liver. It can cause gastric upset if given on an empty stomach, so I would recommend just giving with some food. If you see changes in urination or drinking habits you can have him checked out for his kidneys, but this medication should be fine for Danny. I would only just check out how much Danny weighs. The normal dose for Amoxicillin/Clavulanic Acid is 12.5mg/kg, so I would be giving 375mg every 12 hours to Danny assuming he weighs 30kg. Antibiotics have very large ranges in terms of dosing, and different countries will have slightly different formulations, so I would check this with your vet, as the dose may be higher with the specific compounding that your vet uses.

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    Answered By Destini R. Holloway, DVM

    Veterinarian

    Published on March 19th, 2017

    Antibiotics in theory don't negatively affect the liver or kidneys as long as these organs are healthy. Antibiotics have to be metabolized in order for them to provide benefit to the pet, and the liver metabolizes them, while the kidneys excrete the by-products in the urine. This is a normal process. So unless Bruno has an underlying condition then using this medication doesn't pose any risk to those organs. However if you have concerns about Bruno based on any clinical symptoms (i.e. Vomiting, diarrhea, lethargy, or lack of improvement) then you can always get blood testing to check the organ function. The bile acid test is the specific liver function test and the SDMA test will check for early signs of kidney problems in pets. But again I would not expect your pet to spontaneously develop kidney or liver problems after a short course of antibiotic treatment.

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