Do heartworm & flea meds interact with dog's potassium bromide?

Question

My 13 year old dog is on potassium bromide for seizures. Will her heartworm medicine and oral flea medicine interfere. Pet's info: Dog | Mixed Breed Large (61lb +) | Female | spayed | 12 years and 7 months old | 65 lbs

Lauren Jones VMD · Accepted Answer

Great question! As far as actual drug interactions, there is no concern with administering potassium bromide with any oral or topical heartworm or flea/tick preventatives. Some oral flea and tick preventatives (such as Nexgard and Comfortis/Trifexis) state to administer with caution in dogs with a history of seizures. That said, these results come from a controlled studies where several of the dogs had a history of seizures prior to the administration of these medications. On a personal side note, I give my own 10 year old dog Nexgard and Heartgard as well as potassium bromide for seizure control without hesitation. I do not feel that the studies are controlled well enough to indicate a causal relationship between Nexgard and seizure activity. That said, if you have major concerns, you can always use a topical flea/tick preventative, such as Advantix.

Do heartworm & flea meds interact with dog's potassium bromide?

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