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My dog ate Tri-Heart Plus heartworm medicine. Is it safe for her?

Updated On September 23rd, 2025

Pet's info: Dog | Mixed Breed | Female | spayed | 1 year and 1 month old

My 13mo old 10 lb. shorkie just ate 6 tablets of Tri-Heart Plus for dogs up to 25 lbs.I haven't been able to locate a vet that is open this time of n.

4 Answers

Most Helpful Answer

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Answered By Dr. Melanie, BVSc MS

Veterinarian

Published on June 23rd, 2016

You did exactly the right thing by calling around to vets to ask for help right away. It's always best to check when you aren't sure, and are worried about your pet. The Triheart dose that we give dogs for heart worms has very small doses of the two medications that are in it. Ivermectin is one of the medications that is in the Tri heart. The dose is 68 micrograms. Veterinarians use this medication also to treat dogs with skin mites and use a dose over 100 times the dose in one heart worm preventive tablet. Therefore, even if she would have eaten two or three boxes of the Triheart she should be very safe and there is not any risk of an overdose of the ivermectin. The other medication is called pyrantel pamoate which is used for deworming of intestinal parasites. This medication has a very large safety margin also, and can be given at 10-20 times the normal dose without any risks of toxicity. Therefore, just like with the ivermectin in the Triheart Plus, I would not expect any potential side effects either. These potential side effects could include an upset stomach, mild diarrhea, and/or vomiting. Monitor her for those side effects, and bring her into your vet in the morning if you are still concerned.

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Other Answers

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    Answered By Andrea M. Brodie, DVM

    Veterinarian

    Published on

    The TriHeart dose that vets give dogs for heart worms contains a very low dose of Ivermectin and pyrantel pamoate and at the dose your dog ate the TriHeart, there is extremely little chance that she will get overdosed. Both medications have a very large safety margin and I would not expect any potential side effects Since she ate a large amount of chews she may get an upset stomach, although this is unlikely also. Watch for mild diarrhea or vomiting, just in case.

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    30Pet Parents found this answer helpful

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    Answered By Dr. Melanie, BVSc MS

    Veterinarian

    Published on April 17th, 2019

    No need to be concerned! Heartgard is a very safe medication, and toxicity is only seen if the dog is given an excessive amount of the medication, like 10-20 times the recommended amount. Barry Allen will be fine.

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    Answered By David Elbeze, DVM, MRCVS

    Veterinarian

    Published on December 8th, 2016

    The amount of Ivermectin, which is the potentially toxic ingredient, is still very low in those tablets, you should not see any signs of toxicity even after the ingestion of a double dose. Just in case, here are the signs you should be aware of, if you see any of those you should take him to the vet right away: depression, ataxia, tremors, drooling, paresis, recumbency, excitability, stupor, coma

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    2Pet Parents found this answer helpful

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