###Yes, but... Veterinarians sometimes use Zyrtec, an antihistamine, in the treatment of mild to moderate itching associated with seasonal and/or environmental allergies. Zyrtec is a human medication that is relatively successful and safe for use in animals in an extra-label manner. Both short-term allergy flare-ups and long-term chronic allergies can be managed with Zyrtec, but long-term use should be monitored under the care of a licensed veterinarian. Reported side effects include: drowsiness, excessive salivation, and vomiting. Many things can cause itching and inflammation, including parasites, allergies, food hypersensitivity, and bacterial or fungal infections. Antihistamine medications like Zyrtec can certainly be beneficial in the management of allergies, but they are not a substitute for a thorough veterinary evaluation. Additional medication or alternative treatment may be needed for your pet. In addition, different antihistamines may work differently for different animals. Even in people, Zyrtec may work well for one person, but Claritin works better for someone else, and the same goes for pets. If Zyrtec doesn’t seem to be helping your cat, discuss alternative options with your veterinarian. If you follow the dosing guidelines and use as directed, Zyrtec is pretty safe for your kitty. Always discuss long-term use of Zyrtec with your veterinarian before use. Discontinue use if symptoms are worsening or you notice any side effects. A good rule of thumb to follow for all medications and concerns about your pets is: when in doubt, ask the experts! You are your pet’s advocate - be involved, stay informed! **If you decide to use it...** Here are a few guidelines: 1. Zyrtec comes in 5 and 10 milligram (mg) tablets. Purchase the 5 mg tablets for cats. Only use **plain Zyrtec (cetirizine)** for cats. **NEVER use Zyrtec-D** due to the potential for serious side effects! 2. **The dose for cats** is 5 mg per day. The dose can be split in two by giving 2.5 mg (1/2 tablet) twice daily. 3. If you opt for twice daily dosing, invest in a **pill cutter** to assure that the dose is accurate. Pill cutters can be found in most pharmacies.